I was in the market for digital frames and bought 2 to compare them -- this one b/c of the high user reviews and an HP one b/c of consumer reports reviews.
Both were very easy to use -- just plug the frame into the USB port and drag and drop the pictures onto the frame, or plug your memory card into the digital frame and drag and drop that way.
The biggest 2 differences I found were the "view order" and the internal memory.
The Sony one has 2 choices to view the pictures -- random and "by date". If you are the kind of user who copies pictures onto the frame directly from the memory card, then the date is the date the camera timestamps the picture. However, if you are the kind of user who likes to edit the picture on your computer first and copy if to the frame via the USB port, then the date is the last modified date. This means if you edit your pictures out of date order, the pictures will appear on the frame in the wrong order chronologically. Also, using the USB method takes up more space on the internal memory of the frame, i.e. less pictures.
The HP frame had twice as much internal memory. Also, best I could tell, the order the pictures show is the order you drag and drop them onto the frame.
In summary, if you don't like editing pictures and just want to drag and drop directly from your memory card, then this frame is the way to go. However, if you like to edit pictures, then you might want to look at other alternatives.